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The intracellular metabolism theory explains how and why remarkable dissociation between anabolic and androgenic effects can occur, but why dissociation is invariably incomplete.
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A 2006 study of two pairs of identical twins, in which one twin used aas and the other did not, found that in both cases the steroid-using twin exhibited high levels of aggressiveness, hostility, anxiety, and paranoid ideation not found in the control twin.
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 according to the intracellular metabolism explanation, the androgenic-to-anabolic ratio of a given ar agonist is based on its capacity to be transformed by the aforementioned enzymes in conjunction with the ar activity of any resulting products.
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A 1992 review found that aas may both relieve and cause depression, and that cessation or diminished use of aas may also result in depression, but called for additional studies due to disparate data.
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 however, women with complete androgen insensitivity syndrome (cais), who have a male genotype (46,xy) but a defect in the ar such that it is non-functional, show a perfectly female phenotype despite having testosterone levels in the high end of the normal male range.